Genetic studies of quantitative MCI and AD phenotypes in ADNI: Progress, opportunities, and plans.

ABSTRACT:

Introduction

Genetic data from the Alzheimer's Disease Neuroimaging Initiative (ADNI) have been crucial in advancing the understanding of Alzheimer's disease (AD) pathophysiology. Here, we provide an update on sample collection, scientific progress and opportunities, conceptual issues, and future plans.

Methods

Lymphoblastoid cell lines and DNA and RNA samples from blood have been collected and banked, and data and biosamples have been widely disseminated. To date, APOE genotyping, genome-wide association study (GWAS), and whole exome and whole genome sequencing data have been obtained and disseminated.

Results

ADNI genetic data have been downloaded thousands of times, and >300 publications have resulted, including reports of large-scale GWAS by consortia to which ADN

SUBMITTER: Saykin AJ 

PROVIDER: S-EPMC4510473 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature