A strategy for the identification of combinatorial bioactive compounds contributing to the holistic effect of herbal medicines.

ABSTRACT: It has been well claimed that herbal medicines (HMs) elicit effects via a multi-compounds and multi-targets synergistic mode. However, it lacks appropriate strategies to uncover the combinatory compounds that take effect together and contribute to a certain pharmacological effect of an herb as a whole, which represents a major bottleneck in providing sound evidence in supporting the clinic benefits of HMs. Here, we proposed a strategy to the identification of combinatory compounds contributing to the anti-inflammatory activity of Cardiotonic Pill (CP). The strategy proposed herein contains four core steps, including the identification of bioequivalent combinatorial compounds, chemical family classification-based combinatorial screen, interactive mode evaluation, and activity contribution i

SUBMITTER: Long F 

PROVIDER: S-EPMC4510521 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature