A transport and retention mechanism for the sustained distal localization of Spn-F-IKKε during Drosophila bristle elongation.

ABSTRACT: Stable localization of the signaling complex is essential for the robust morphogenesis of polarized cells. Cell elongation involves molecular signaling centers that coordinately regulate intracellular transport and cytoskeletal structures. In Drosophila bristle elongation, the protein kinase IKKε is activated at the distal tip of the growing bristle and regulates the shuttling movement of recycling endosomes and cytoskeletal organization. However, how the distal tip localization of IKKε is established and maintained during bristle elongation is unknown. Here, we demonstrate that IKKε distal tip localization is regulated by Spindle-F (Spn-F), which is stably retained at the distal tip and functions as an adaptor linking IKKε to cytoplasmic dynein. We found that Javelin-like (Jvl) is a key r

SUBMITTER: Otani T 

PROVIDER: S-EPMC4510591 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature