TNF-α, TNF-β and IL-10 gene polymorphism and association with oral lichen planus risk in Saudi patients.

ABSTRACT:

Objectives

Oral lichen planus (OLP) is a chronic inflammatory oral mucosal disease. Cytokines play an important role in the pathogenesis and disease progression of OLP. Various reports have implicated cytokine gene polymorphisms in susceptibility to develop some immune mediated conditions including OLP. The purpose of this study was to investigate the association of tumor necrosis factor (TNF)-α, TNF-β and interleukin (IL)-10 gene polymorphisms with the OLP risk.

Material and methods

Forty two unrelated patients with OLP and 211 healthy volunteers were genotyped for TNF-α (-308 G/A), TNF-β (+252A/G), IL-10 (-1082G/A), IL-10 (-819C/T), and IL-10 (-592C/A) polymorphisms.

Results

The frequencies of allele A and genotype GA of TNF-α (-308G/A) were significantly higher whi

SUBMITTER: Al-Mohaya MA 

PROVIDER: S-EPMC4510664 | biostudies-literature | 2015 May-Jun

REPOSITORIES: biostudies-literature