A dynamic intracellular distribution of Vangl2 accompanies cell polarization during zebrafish gastrulation.

ABSTRACT: During vertebrate gastrulation, convergence and extension movements elongate embryonic tissues anteroposteriorly and narrow them mediolaterally. Planar cell polarity (PCP) signaling is essential for mediolateral cell elongation underlying these movements, but how this polarity arises is poorly understood. We analyzed the elongation, orientation and migration behaviors of lateral mesodermal cells undergoing convergence and extension movements in wild-type zebrafish embryos and mutants for the Wnt/PCP core component Vangl2 (Trilobite). We demonstrate that Vangl2 function is required at the time when cells transition to a highly elongated and mediolaterally aligned body. vangl2 mutant cells fail to undergo this transition and to migrate along a straight path with high net speed towards the do

SUBMITTER: Roszko I 

PROVIDER: S-EPMC4510859 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature