Multilocus microsatellite typing of Leishmania infantum isolates in monitored Leishmania/HIV coinfected patients.

ABSTRACT:

Background

Leishmania infantum is the main etiological agent of both visceral and cutaneous clinical forms of leishmaniasis in the Mediterranean area. Leishmania/HIV coinfection in this area is characterized by a chronic course and frequent recurrences of clinical episodes. The present study using Multilocus Microsatellite Typing (MLMT) analysis, a highly discriminative tool, aimed to genetically characterize L. infantum isolates taken from monitored Leishmania/HIV coinfected patients presenting successive clinical episodes.

Methods

In this study, by the analysis of 20 microsatellite loci, we studied the MLMT profiles of 25 L. infantum isolates from 8 Leishmania/HIV coinfected patients who had experienced several clinical episodes. Two to seven isolates per patient were take

SUBMITTER: Tomas-Perez M 

PROVIDER: S-EPMC4511019 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature