Locomotion and Task Demands Differentially Modulate Thalamic Audiovisual Processing during Active Search.

ABSTRACT: Active search is a ubiquitous goal-driven behavior wherein organisms purposefully investigate the sensory environment to locate a target object. During active search, brain circuits analyze a stream of sensory information from the external environment, adjusting for internal signals related to self-generated movement or "top-down" weighting of anticipated target and distractor properties. Sensory responses in the cortex can be modulated by internal state, though the extent and form of modulation arising in the cortex de novo versus an inheritance from subcortical stations is not clear. We addressed this question by simultaneously recording from auditory and visual regions of the thalamus (MG and LG, respectively) while mice used dynamic auditory or visual feedback to search for a hidden ta

SUBMITTER: Williamson RS 

PROVIDER: S-EPMC4511122 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature