Identification and Characterization of the Androgen Receptor From the American Alligator, Alligator mississippiensis.

ABSTRACT: Androgens are essential for the development, reproduction, and health throughout the life span of vertebrates, particularly during the initiation and maintenance of male sexual characteristics. Androgen signaling is mediated by the androgen receptor (AR), a member of the steroid nuclear receptor superfamily. Mounting evidence suggests that environmental factors, such as exogenous hormones or contaminants that mimic hormones, can disrupt endocrine signaling and function. The American alligator (Alligator mississippiensis), a unique model for ecological research in that it exhibits environment-dependent sex determination, is oviparous and long lived. Alligators from a contaminated environment exhibit low reproductive success and morphological disorders of the testis and phallus in neonates a

SUBMITTER: Miyagawa S 

PROVIDER: S-EPMC4511131 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature