Variations in genes involved in dormancy associated with outcome in patients with resected colorectal liver metastases.

ABSTRACT:

Background

Tumor dormancy has been described as a state of hibernation. Dormancy can be switched to proliferation by different pathways, which may play a critical role in tumor recurrence. In this study, we investigated genetic variations within genes involved in tumor dormancy and their association with recurrence and outcome in patients with colorectal liver metastases (CLM) who underwent neoadjuvant bevacizumab-based chemotherapy.

Patients and methods

Genomic DNA was extracted from resected CLM (FFPE) from 149 patients. Single-nucleotide polymorphisms (SNPs) in 14 genes associated with dormancy were analyzed by direct Sanger DNA sequencing and evaluated for response, recurrence-free survival (RFS), overall survival (OS) and recurrence patterns.

Results

NME1 rs34214

SUBMITTER: Stremitzer S 

PROVIDER: S-EPMC4511220 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature