Associations of SNPs located at candidate genes to bovine growth traits, prioritized with an interaction networks construction approach.

ABSTRACT:

Background

For most domestic animal species, including bovines, it is difficult to identify causative genetic variants involved in economically relevant traits. The candidate gene approach is efficient because it investigates genes that are expected to be associated with the expression of a trait and defines whether the genetic variation present in a population is associated with phenotypic diversity. A potential limitation of this approach is the identification of candidates. This study used a bioinformatics approach to identify candidate genes via a search guided by a functional interaction network.

Results

A functional interaction network tool, BosNet, was constructed for Bos taurus. Predictions for candidate genes were performed using the guilt-by-association principle i

SUBMITTER: Paredes-Sanchez FA 

PROVIDER: S-EPMC4511253 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature