Red blood cell fatty acids and biomarkers of inflammation: a cross-sectional study in a community-based cohort.

ABSTRACT:

Introduction

Inflammation and inflammatory biomarkers have emerged as integral components and predictors of incident cardiovascular (CV) disease. Omega-3 fatty acids, particularly eicosapentaenoic and docosahexaenoic acids (EPA and DHA) have anti-inflammatory properties, and have been variably associated with lower blood pressure, favorable blood lipid changes, and reduced CV events.

Methods and results

We examined the cross-sectional association of red blood cell (RBC) fatty acids, representative of body membrane fatty acid composition, with 10 biomarkers active in multiple inflammatory pathways in 2724 participants (mean age 66 ± 9 years, 54% women, 8% minorities) from the Framingham Offspring and minority Omni Cohorts. After multivariable adjustment, the RBC EPA and DHA c

SUBMITTER: Fontes JD 

PROVIDER: S-EPMC4511480 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature