Quantifying selective pressures driving bacterial evolution using lineage analysis.

ABSTRACT: Organisms use a variety of strategies to adapt to their environments and maximize long-term growth potential, but quantitative characterization of the benefits conferred by the use of such strategies, as well as their impact on the whole population's rate of growth, remains challenging. Here, we use a path-integral framework that describes how selection acts on lineages -i.e. the life-histories of individuals and their ancestors- to demonstrate that lineage-based measurements can be used to quantify the selective pressures acting on a population. We apply this analysis to E. coli bacteria exposed to cyclical treatments of carbenicillin, an antibiotic that interferes with cell-wall synthesis and affects cells in an age-dependent manner. While the extensive characterization of

SUBMITTER: Lambert G 

PROVIDER: S-EPMC4511495 | biostudies-literature | 2015 Jan-Mar

REPOSITORIES: biostudies-literature