TMEM140 is associated with the prognosis of glioma by promoting cell viability and invasion.

ABSTRACT:

Background

Gliomas are the most common types of primary brain tumors in the adult central nervous system. TMEM140 is identified as an amplified gene in the human gastric cancer genome. However, the function of TMEM140 in gliomas has not been thoroughly elucidated. The aim of the current study was to determine the clinical significance of TMEM140 expression in patients with gliomas and its effect on tumor cell malignant phenotypes.

Methods

Immunohistochemical analysis and real-time reverse transcription PCR were performed to detect the expression levels of TMEM140 in 70 glioma brain tissue samples. Next, the correlation between the TMEM140 expression levels and the clinical characteristics and outcomes of glioma patients was statistically analyzed. TMEM140 expression was inhi

SUBMITTER: Li B 

PROVIDER: S-EPMC4511541 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature