Decoupling of structural and functional brain connectivity in older adults with white matter hyperintensities.

ABSTRACT: Age-related impairments in the default network (DN) have been related to disruptions in connecting white matter tracts. We hypothesized that the local correlation between DN structural and functional connectivity is negatively affected in the presence of global white matter injury. In 125 clinically normal older adults, we tested whether the relationship between structural connectivity (via diffusion imaging tractography) and functional connectivity (via resting-state functional MRI) of the posterior cingulate cortex (PCC) and medial prefrontal frontal cortex (MPFC) of the DN was altered in the presence of white matter hyperintensities (WMH). A significant correlation was observed between microstructural properties of the cingulum bundle and MPFC-PCC functional connectivity in individuals

SUBMITTER: Reijmer YD 

PROVIDER: S-EPMC4511724 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature