A multi-locus likelihood method for assessing parent-of-origin effects using case-control mother-child pairs.

ABSTRACT: Parent-of-origin effects have been pointed out to be one plausible source of the heritability that was unexplained by genome-wide association studies. Here, we consider a case-control mother-child pair design for studying parent-of-origin effects of offspring genes on neonatal/early-life disorders or pregnancy-related conditions. In contrast to the standard case-control design, the case-control mother-child pair design contains valuable parental information and therefore permits powerful assessment of parent-of-origin effects. Suppose the region under study is in Hardy-Weinberg equilibrium, inheritance is Mendelian at the diallelic locus under study, there is random mating in the source population, and the SNP under study is not related to risk for the phenotype under study because of link

SUBMITTER: Lin D 

PROVIDER: S-EPMC4511966 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature