Improving Adiponectin Levels in Individuals With Diabetes and Obesity: Insights From Look AHEAD.

ABSTRACT:

Objective

This study investigated whether fitness changes resulting from lifestyle interventions for weight loss may independently contribute to the improvement of low adiponectin levels in obese individuals with diabetes.

Research design and methods

Look AHEAD (Action for Health in Diabetes) randomized overweight/obese individuals with type 2 diabetes to intensive lifestyle intervention (ILI) for weight loss or to diabetes support and education (DSE). Total and high-molecular weight adiponectin (adiponectins), weight, and cardiorespiratory fitness (submaximal exercise stress test) were measured in 1,397 participants at baseline and at 1 year, when ILI was most intense. Regression analyses examined the associations of 1-year weight and fitness changes with change in adiponec

SUBMITTER: Belalcazar LM 

PROVIDER: S-EPMC4512135 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature