Gene-Environment Interactions of Circadian-Related Genes for Cardiometabolic Traits.

ABSTRACT:

Objective

Common circadian-related gene variants associate with increased risk for metabolic alterations including type 2 diabetes. However, little is known about whether diet and sleep could modify associations between circadian-related variants (CLOCK-rs1801260, CRY2-rs11605924, MTNR1B-rs1387153, MTNR1B-rs10830963, NR1D1-rs2314339) and cardiometabolic traits (fasting glucose [FG], HOMA-insulin resistance, BMI, waist circumference, and HDL-cholesterol) to facilitate personalized recommendations.

Research design and methods

We conducted inverse-variance weighted, fixed-effect meta-analyses of results of adjusted associations and interactions between dietary intake/sleep duration and selected variants on cardiometabolic traits from 15 cohort studies including up to 28,190 par

SUBMITTER: Dashti HS 

PROVIDER: S-EPMC4512139 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature