Transferring genomics to the clinic: distinguishing Burkitt and diffuse large B cell lymphomas.

ABSTRACT:

Background

Classifiers based on molecular criteria such as gene expression signatures have been developed to distinguish Burkitt lymphoma and diffuse large B cell lymphoma, which help to explore the intermediate cases where traditional diagnosis is difficult. Transfer of these research classifiers into a clinical setting is challenging because there are competing classifiers in the literature based on different methodology and gene sets with no clear best choice; classifiers based on one expression measurement platform may not transfer effectively to another; and, classifiers developed using fresh frozen samples may not work effectively with the commonly used and more convenient formalin fixed paraffin-embedded samples used in routine diagnosis.

Methods

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SUBMITTER: Sha C 

PROVIDER: S-EPMC4512160 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature