Molecular and Genetic Characterization of Depression: Overlap with other Psychiatric Disorders and Aging.

ABSTRACT: Genome-wide expression and genotyping technologies have uncovered the genetic bases of complex diseases at unprecedented rates; However despite its heavy burden and high prevalence, the molecular characterization of major depressive disorder (MDD) has lagged behind. Transcriptome studies report multiple brain disturbances but are limited by small sample sizes. Genome-wide association studies (GWAS) report weak results but suggest overlapping genetic risk with other neuropsychiatric disorders. We performed systematic molecular characterization of altered brain function in MDD, using meta-analysis of differential expression in eight gene array studies in three corticolimbic brain regions in 101 subjects. The identified "metaA-MDD" genes suggest altered neurotrophic support, brain plasticity

SUBMITTER: Ding Y 

PROVIDER: S-EPMC4512183 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature