Ontology highlight
ABSTRACT:
SUBMITTER: Basu B
PROVIDER: S-EPMC4512239 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Basu Bristi B Dean Emma E Puglisi Martina M Greystoke Alastair A Ong Michael M Burke Wendy W Cavallin Maria M Bigley Graham G Womack Christopher C Harrington Elizabeth A EA Green Stephen S Oelmann Elisabeth E de Bono Johann S JS Ranson Malcolm M Banerji Udai U
Clinical cancer research : an official journal of the American Association for Cancer Research 20150324 15
<h4>Purpose</h4>AZD2014 is a novel, oral, m-TORC 1/2 inhibitor that has shown in vitro and in vivo efficacy across a range of preclinical human cancer models.<h4>Experimental design</h4>A rolling six-dose escalation was performed to define an MTD (part A), and at MTD a further cohort of patients was treated to further characterize toxicities and perform pre- and posttreatment biopsies (part B). AZD2014 was administered orally twice a day continuously. Flow cytometry, ELISA, and immunohistochemis ...[more]