Tissue Remodelling following Resection of Porcine Liver.

ABSTRACT:

Aim

To study genes regulating the extracellular matrix (ECM) and investigate the tissue remodelling following liver resection in porcine.

Methods

Four pigs with 60% partial hepatectomy- (PHx-) induced liver regeneration were studied over six weeks. Four pigs underwent sham surgery and another four pigs were used as controls of the normal liver growth. Liver biopsies were taken upon laparotomy, after three and six weeks. Gene expression profiles were obtained using porcine-specific oligonucleotide microarrays. Immunohistochemical staining was performed and a proliferative index was assessed.

Results

More differentially expressed genes were associated with the regulation of ECM in the resection group compared to the sham and control groups. Secreted protein acidic and r

SUBMITTER: Nygard IE 

PROVIDER: S-EPMC4512564 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature