Mitochondrial DNA variants can mediate methylation status of inflammation, angiogenesis and signaling genes.

ABSTRACT: Mitochondrial (mt) DNA can be classified into haplogroups representing different geographic and/or racial origins of populations. The H haplogroup is protective against age-related macular degeneration (AMD), while the J haplogroup is high risk for AMD. In the present study, we performed comparison analyses of human retinal cell cybrids, which possess identical nuclei, but mtDNA from subjects with either the H or J haplogroups, and demonstrate differences in total global methylation, and expression patterns for two genes related to acetylation and five genes related to methylation. Analyses revealed that untreated-H and -J cybrids have different expression levels for nuclear genes (CFH, EFEMP1, VEGFA and NFkB2). However, expression levels for these genes become equivalent after treatment w

SUBMITTER: Atilano SR 

PROVIDER: S-EPMC4512622 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature