Left Ventricular T-Cell Recruitment Contributes to the Pathogenesis of Heart Failure.

ABSTRACT:

Background

Despite the emerging association between heart failure (HF) and inflammation, the role of T cells, major players in chronic inflammation, has only recently begun to be explored. Whether T-cell recruitment to the left ventricle (LV) participates in the development of HF requires further investigation to identify novel mechanisms that may serve for the design of alternative therapeutic interventions.

Methods and results

Real-time videomicroscopy of T cells from nonischemic HF patients or from mice with HF induced by transverse aortic constriction revealed enhanced adhesion to activated vascular endothelial cells under flow conditions in vitro compared with T cells from healthy subjects or sham mice. T cells in the mediastinal lymph nodes and the intramyocardial endo

SUBMITTER: Nevers T 

PROVIDER: S-EPMC4512916 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature