The Impact of Surface Ligands and Synthesis Method on the Toxicity of Glutathione-Coated Gold Nanoparticles.

ABSTRACT: Gold nanoparticles (AuNPs) are increasingly used in biomedical applications, hence understanding the processes that affect their biocompatibility and stability are of significant interest. In this study, we assessed the stability of peptide-capped AuNPs and used the embryonic zebrafish (Danio rerio) as a vertebrate system to investigate the impact of synthesis method and purity on their biocompatibility. Using glutathione (GSH) as a stabilizer, Au-GSH nanoparticles with identical core sizes were terminally modified with Tryptophan (Trp), Histidine (His) or Methionine (Met) amino acids and purified by either dialysis or ultracentrifugation. Au-GSH-(Trp)₂ purified by dialysis elicited significant morbidity and mortality at 200 μg/mL, Au-GSH-(His)₂ induced morbidi

SUBMITTER: Harper B 

PROVIDER: S-EPMC4512953 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature