Oral Appliance Treatment Response and Polysomnographic Phenotypes of Obstructive Sleep Apnea.

ABSTRACT:

Study objectives

Mandibular advancement splints (MAS) are an effective treatment for obstructive sleep apnea (OSA); however, therapeutic response is variable. Younger age, female gender, less obesity, and milder and supine-dependent OSA have variably been associated with treatment success in relatively small samples. Our objective was to utilize a large cohort of MAS treated patients (1) to compare efficacy across patients with different phenotypes of OSA and (2) to assess demographic, anthropometric, and polysomnography variables as treatment response predictors.

Methods

Retrospective analysis of MAS-treated patients participating in clinical trials in sleep centers in Sydney, Australia between years 2000-2013. All studies used equivalent customized two-piece MAS devices an

SUBMITTER: Sutherland K 

PROVIDER: S-EPMC4513263 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature