Ultraviolet B Inhibits Skin Wound Healing by Affecting Focal Adhesion Dynamics.

ABSTRACT: As the most important interface between human body and external environment, skin acts as an essential barrier preventing various environmental damages, among which DNA-damaging UV radiation from the sun remains the major environmental risk factor causing various skin diseases. It has been well documented that wavelengths in the ultraviolet B (UVB) radiation range (290-320 nm) of the solar spectrum can be absorbed by skin and lead to cutaneous injury and various other deleterious effects. During process such as wound healing, the orchestrated movement of cells in a particular direction is essential and highly regulated, integrating signals controlling adhesion, polarity and the cytoskeleton. Cell adhesion and migration are modulated through both of actin and microtubule cytoskeletons. Howe

SUBMITTER: Liu H 

PROVIDER: S-EPMC4513668 | biostudies-literature | 2015 Jul-Aug

REPOSITORIES: biostudies-literature