Regulatory T lymphocytes and transforming growth factor beta in epithelial ovarian tumors-prognostic significance.

ABSTRACT:

Background

Regulatory T lymphocytes (Treg) are characterized by the presence of CD4+ surface antigen. Today the transcription factor FOXP3 is considered to be the most specific marker of Treg cells. The aim of the study was to estimate the percentage of Treg in peripheral blood and the tissue of the epithelial ovarian tumor and blood serum TGF-beta concentrations and relationships between them. Moreover, the aim of the study was to answer the question whether the percentage of Treg lymphocytes affects the time of survival in patients with ovarian cancer.

Methods

The patients were divided into four groups, depending on the histopathological examination result: I--a group without any pathology within the ovaries (C; n = 20), II--a group with benign tumors (B; n = 25), III - wi

SUBMITTER: Winkler I 

PROVIDER: S-EPMC4513978 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature