Dengue virus specific dual HLA binding T cell epitopes induce CD8+ T cell responses in seropositive individuals.

ABSTRACT: Dengue virus infects an estimated 300 million people each year and even more are at risk of becoming infected as the virus continues to spread into new areas. Despite the increase in viral prevalence, no anti-viral medications or vaccines are approved for treating or preventing infection. CD8+ T cell responses play a major role in viral clearance. Therefore, effective vaccines that induce a broad, multi-functional T cell response with substantial cross-reactivity between all virus serotypes can have major impacts on reducing infection rates and infection related complications. Here, we took an immunoproteomic approach to identify novel MHC class I restricted T cell epitopes presented by dengue virus infected cells, representing the natural and authentic targets of the T cell response. Usin

SUBMITTER: Comber JD 

PROVIDER: S-EPMC4514071 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature