Genetic diversity of the Pneumococcal CbpA: Implications for next-generation vaccine development.

ABSTRACT: Pneumococci are capable of vaccine escape by genetic recombination at the targeted capsular locus, significantly reducing long-term vaccine effectiveness. Recently, efforts have been redirected to understanding pneumococcal biology related to potential next-generation vaccine candidates. A variety of serotype-independent protein antigens capable of inducing protective immune responses in tissue culture and animal models of infection have been identified. However, ideal vaccine candidates that are conserved across all genotypes, provide broad population coverage, and induce T-cell dependent immune responses are still under investigation. We examined whether immune responses due to the highly polymorphic CbpA antigen are due to a conserved domain capable of evoking specific immune "memory" a

SUBMITTER: Abry MF 

PROVIDER: S-EPMC4514174 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature