Generation and Characterization of Novel Magnetic Field-Responsive Biomaterials.

ABSTRACT: We report the preparation of novel magnetic field-responsive tissue substitutes based on biocompatible multi-domain magnetic particles dispersed in a fibrin-agarose biopolymer scaffold. We characterized our biomaterials with several experimental techniques. First we analyzed their microstructure and found that it was strongly affected by the presence of magnetic particles, especially when a magnetic field was applied at the start of polymer gelation. In these samples we observed parallel stripes consisting of closely packed fibers, separated by more isotropic net-like spaces. We then studied the viability of oral mucosa fibroblasts in the magnetic scaffolds and found no significant differences compared to positive control samples. Finally, we analyzed the magnetic and mechanical properties

SUBMITTER: Lopez-Lopez MT 

PROVIDER: S-EPMC4514776 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature