Elevated Serum Gas6 Is a Novel Prognostic Biomarker in Patients with Oral Squamous Cell Carcinoma.

ABSTRACT:

Objective

This study explored the level and clinical significance of serum Gas6 in patients with oral squamous cell carcinoma (OSCC).

Methods

A total of 128 OSCC patients and 145 normal controls were selected. Enzyme-linked immunosorbent assay was used to detect Gas6 concentration in sera from the OSCC patients and controls. The correlations of serum Gas6 concentration and clinicopathological characteristics of OSCC patients were assessed, and the prognostic significance of serum Gas6 was evaluated with a Kaplan-Meier curve and log-rank test.

Results

The results showed that serum Gas6 concentration was significantly higher in OSCC patients than in controls (P < 0.05). OSCC patients with late TNM stage (III, IV) had a relatively high serum Gas6 concentration compared w

SUBMITTER: Jiang T 

PROVIDER: S-EPMC4514879 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature