Ontology highlight
ABSTRACT:
SUBMITTER: Balogh A
PROVIDER: S-EPMC4514920 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Balogh Andrea A Shimizu Yoshibumi Y Lee Sue Chin SC Norman Derek D DD Gangwar Ruchika R Bavaria Mitul M Moon ChangSuk C Shukla Pradeep P Rao Radakrishna R Ray Ramesh R Naren Anjaparavanda P AP Banerjee Souvik S Miller Duane D DD Balazs Louisa L Pelus Louis L Tigyi Gabor G
Cellular signalling 20150528 9
In this study we characterized the effects of radiation injury on the expression and function of the autotaxin (ATX)-LPA2 GPCR axis. In IEC-6 crypt cells and jejunum enteroids quantitative RT-PCR showed a time- and dose-dependent upregulation of lpa2 in response to γ-irradiation that was abolished by mutation of the NF-κB site in the lpa2 promoter or by inhibition of ATM/ATR kinases with CGK-733, suggesting that lpa2 is a DNA damage response gene upregulated by ATM via NF-κB. The resolution kine ...[more]