4DGenome: a comprehensive database of chromatin interactions.

ABSTRACT:

Motivation

The 3D structure of the genome plays a critical role in regulating gene expression. Recent progress in mapping technologies for chromatin interactions has led to a rapid increase in this kind of interaction data. This trend will continue as research in this burgeoning field intensifies.

Results

We describe the 4DGenome database that stores chromatin interaction data compiled through comprehensive literature curation. The database currently covers both low- and high-throughput assays, including 3C, 4C-Seq, 5C, Hi-C, ChIA-PET and Capture-C. To complement the set of interactions detected by experimental assays, we also include interactions predicted by a recently developed computational method with demonstrated high accuracy. The database currently contains ∼8 millio

SUBMITTER: Teng L 

PROVIDER: S-EPMC4514924 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature