DISSCO: direct imputation of summary statistics allowing covariates.

ABSTRACT:

Background

Imputation of individual level genotypes at untyped markers using an external reference panel of genotyped or sequenced individuals has become standard practice in genetic association studies. Direct imputation of summary statistics can also be valuable, for example in meta-analyses where individual level genotype data are not available. Two methods (DIST and ImpG-Summary/LD), that assume a multivariate Gaussian distribution for the association summary statistics, have been proposed for imputing association summary statistics. However, both methods assume that the correlations between association summary statistics are the same as the correlations between the corresponding genotypes. This assumption can be violated in the presence of confounding covariates.

Methods

SUBMITTER: Xu Z 

PROVIDER: S-EPMC4514926 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature