Associations of lipid levels susceptibility loci with coronary artery disease in Chinese population.

ABSTRACT:

Background

Recent genome-wide association studies (GWAS) have identified several single nucleotide polymorphisms (SNPs) that were associated with blood lipid levels in Caucasians. This study investigated whether these loci influenced lipid levels and whether they were associated with the risk of coronary artery disease (CAD) and its angiographic severity in Chinese population.

Methods

Six SNPs were genotyped in 1100 CAD cases and 1069 controls using the high-resolution melting (HRM) method. Coronary atherosclerosis severity was assessed by the vessel scores and the Gensini scoring system.

Results

Among the 6 SNPs and the genetic risks scores (GRS), the minor alleles of HNF1A rs1169288 (odd ratio (OR) = 1.18, 95% confidence interval (CI) 1.05-1.33, P = 0.006) and MADD-

SUBMITTER: Wang XB 

PROVIDER: S-EPMC4514971 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature