MMPs/TIMPs and inflammatory signalling de-regulation in human incisional hernia tissues.

ABSTRACT:

Background

Incisional hernia is a common and important complication of laparotomies. Epidemiological studies allude to an underlying biological cause, at least in a subset of population. Interest has mainly focused on abnormal collagen metabolism. However, the role played by other determinants of extracellular matrix (ECM) composition is unknown. To date, there are few laboratory studies investigating the importance of biological factors contributing to incisional hernia development. We performed a descriptive tissue-based analysis to elucidate the possible relevance of matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) in association with local cytokine induction in human incisional hernia tissues. The expression profiles of MMPs, TIMPs and pro-inflammatory cytok

SUBMITTER: Guillen-Marti J 

PROVIDER: S-EPMC4515059 | biostudies-literature | 2009 Nov-Dec

REPOSITORIES: biostudies-literature