Hepatic stellate cell and monocyte interaction contributes to poor prognosis in hepatocellular carcinoma.

ABSTRACT:

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Hepatocellular carcinoma (HCC) patients suffer from a poor survival rate and a high incidence of postoperative recurrence. The hepatic microenvironment plays a significant role in the initiation, progression, and recurrence of HCC; however, the causal mechanisms of these phenomena are unclear. Given the predominant underlying fibrotic and cirrhotic conditions of the liver prone to HCC and its recurrence, alterations of components of the inflammatory milieu have been suggested as factors that promote HCC development. In particular, activated hepatic stellate cells (A-HSCs), which play a key role in liver fibrosis and cirrhosis, have been suggested as contributors to the HCC-prone microenvironment. Here, we have identified and validated an A-HSC-specific gene expression si

SUBMITTER: Ji J 

PROVIDER: S-EPMC4515211 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature