Interleukin-18 genetic polymorphisms contribute differentially to the susceptibility to Crohn's disease.

ABSTRACT:

Aim

To investigate the correlation between interleukin-18 (IL-18) gene polymorphisms and the risk of developing Crohn's disease (CD).

Methods

The PubMed, CISCOM, CINAHL, Web of Science, EBSCO, Cochrane Library, MEDLINE, EMBASE and CBM databases were searched without any language restrictions using combinations of keywords relating to CD and IL-18 for relevant articles published before November 1(st), 2013. Screening of the published studies retrieved from searches was based on our stringent inclusion and exclusion criteria and resulted in seven eligible studies for meta-analysis. A meta-analysis was conducted using a random-effects model with STATA 12.0 software. Crude odds ratios (ORs) with 95% confidence intervals (95%CI) were calculated.

Results

Seven case-control

SUBMITTER: Gao SJ 

PROVIDER: S-EPMC4515852 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature