Metabolomics and transcriptomics identify pathway differences between visceral and subcutaneous adipose tissue in colorectal cancer patients: the ColoCare study.

ABSTRACT:

Background

Metabolic and transcriptomic differences between visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) compartments, particularly in the context of obesity, may play a role in colorectal carcinogenesis. We investigated the differential functions of their metabolic compositions.

Objectives

Biochemical differences between adipose tissues (VAT compared with SAT) in patients with colorectal carcinoma (CRC) were investigated by using mass spectrometry metabolomics and gene expression profiling. Metabolite compositions were compared between VAT, SAT, and serum metabolites. The relation between patients' tumor stage and metabolic profiles was assessed.

Design

Presurgery blood and paired VAT and SAT samples during tumor surgery were obtained from 59 C

SUBMITTER: Liesenfeld DB 

PROVIDER: S-EPMC4515859 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature