Neuropeptide Y genotype, central obesity, and abdominal fat distribution: the POUNDS LOST trial.

ABSTRACT:

Background

Neuropeptide Y is a key peptide affecting adiposity and has been related to obesity risk. However, little is known about the role of NPY variations in diet-induced change in adiposity.

Objective

The objective was to examine the effects of NPY variant rs16147 on central obesity and abdominal fat distribution in response to dietary interventions.

Design

We genotyped a functional NPY variant rs16147 among 723 participants in the Preventing Overweight Using Novel Dietary Strategies trial. Changes in waist circumference (WC), total abdominal adipose tissue, visceral adipose tissue, and subcutaneous adipose tissue (SAT) from baseline to 6 and 24 mo were evaluated with respect to the rs16147 genotypes. Genotype-dietary fat interaction was also examined.

Results

SUBMITTER: Lin X 

PROVIDER: S-EPMC4515864 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature