Impact of early disease factors on metabolic syndrome in systemic lupus erythematosus: data from an international inception cohort.

ABSTRACT:

Background

The metabolic syndrome (MetS) may contribute to the increased cardiovascular risk in systemic lupus erythematosus (SLE). We examined the association between MetS and disease activity, disease phenotype and corticosteroid exposure over time in patients with SLE.

Methods

Recently diagnosed (<15 months) patients with SLE from 30 centres across 11 countries were enrolled into the Systemic Lupus International Collaborating Clinics (SLICC) Inception Cohort from 2000 onwards. Baseline and annual assessments recorded clinical, laboratory and therapeutic data. A longitudinal analysis of factors associated with MetS in the first 2 years of follow-up was performed using random effects logistic regression.

Results

We studied 1150 patients with a mean (SD) age of 34.9 (

SUBMITTER: Parker B 

PROVIDER: S-EPMC4515988 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature