Current smoking status is a strong predictor of radiographic progression in early rheumatoid arthritis: results from the SWEFOT trial.

ABSTRACT:

Objectives

To study clinical predictors for radiographic progression after 1 year in an early rheumatoid arthritis (RA) trial.

Methods

In the SWEFOT trial population, disease modifying antirheumatic drug (DMARD) naïve RA patients started methotrexate; 3-month responders (DAS28 <3.2) continued (n=147), while non-responders were randomised to addition of sulfasalazine+hydroxychloroquine (n=130) or infliximab (n=128). X-rays were scored by the Sharp-van der Hejde score (SHS) method and radiographic progression was defined as a ≥5 increase after 1 year. Potential baseline predictors of radiographic progression were tested using multivariable logistic regression, adjusted for potential confounders.

Results

79 of 311 patients with available radiographs at baseline and follo

SUBMITTER: Saevarsdottir S 

PROVIDER: S-EPMC4515990 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature