Fetal Mammalian Heart Generates a Robust Compensatory Response to Cell Loss.

ABSTRACT:

Background

Heart development is tightly regulated by signaling events acting on a defined number of progenitor and differentiated cardiac cells. Although loss of function of these signaling pathways leads to congenital malformation, the consequences of cardiac progenitor cell or embryonic cardiomyocyte loss are less clear. In this study, we tested the hypothesis that embryonic mouse hearts exhibit a robust mechanism for regeneration after extensive cell loss.

Methods and results

By combining a conditional cell ablation approach with a novel blastocyst complementation strategy, we generated murine embryos that exhibit a full spectrum of cardiac progenitor cell or cardiomyocyte ablation. Remarkably, ablation of up to 60% of cardiac progenitor cells at embryonic day 7.5 was wel

SUBMITTER: Sturzu AC 

PROVIDER: S-EPMC4516129 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature