Clinical Parameters vs Cytokine Profiles as Predictive Markers of IgE-Mediated Allergy in Young Children.

ABSTRACT:

Background

Allergy afflicts one third of children, negatively impacting their quality of life and generating a significant socio-economic burden. To this day, this disorder remains difficult to diagnose early in young patients, with no predictive test available.

Objective

This study was designed to correlate cytokine profiles with clinical phenotypes of allergy development.

Methods

Three hundred patients were recruited and followed from birth to 18 months of age. They were given a clinical exam at birth and at 2, 6, 12, and 18 months of age, with skin prick tests at 6, and 18 months, in order to have a record of their medical history and determine their allergic status. In addition, mononuclear cells from 131 patients were isolated from cord blood and from peripheral

SUBMITTER: Lombard C 

PROVIDER: S-EPMC4516234 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature