Unknown

Dataset Information

0

Evolution of the Helicobacter pylori vacuolating cytotoxin in a human stomach.

ABSTRACT: We describe two subclones of Helicobacter pylori, isolated contemporaneously from a human stomach, which differ markedly in the vacuolating cytotoxin gene, vacA, but whose near identity in sequences outside this locus implies a very recent common origin. The differences are consistent with homologous recombination with DNA from another strain and result in a changed vacA midregion and, importantly, in changed toxicity.

SUBMITTER: Aviles-Jimenez F 

PROVIDER: S-EPMC451639 | biostudies-literature | 2004 Aug

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Evolution of the Helicobacter pylori vacuolating cytotoxin in a human stomach.

Aviles-Jimenez Francisco F   Letley Darren P DP   Gonzalez-Valencia Gerardo G   Salama Nina N   Torres Javier J   Atherton John C JC  

Journal of bacteriology 20040801 15

We describe two subclones of Helicobacter pylori, isolated contemporaneously from a human stomach, which differ markedly in the vacuolating cytotoxin gene, vacA, but whose near identity in sequences outside this locus implies a very recent common origin. The differences are consistent with homologous recombination with DNA from another strain and result in a changed vacA midregion and, importantly, in changed toxicity. ...[more]

Similar Datasets

Unknown Cryo-EM structures of Helicobacter pylori vacuolating cytotoxin A (VacA) oligomeric assemblies
| EMPIAR-10607 | biostudies-other
Unknown Vacuolating cytotoxin of Helicobacter pylori induces apoptosis in the human gastric epithelial cell line AGS.
| S-EPMC98603 | biostudies-literature
Unknown Vacuolating Cytotoxin A Triggers Mitophagy in <i>Helicobacter pylori</i>-Infected Human Gastric Epithelium Cells.
| S-EPMC9329568 | biostudies-literature
Unknown DNA sequence analysis of South African Helicobacter pylori Vacuolating Cytotoxin Gene (vacA).
| S-EPMC3233416 | biostudies-literature
Unknown Natural diversity in the N terminus of the mature vacuolating cytotoxin of Helicobacter pylori determines cytotoxin activity.
| S-EPMC94518 | biostudies-literature
Unknown Heterogeneity in levels of vacuolating cytotoxin gene (vacA) transcription among Helicobacter pylori strains.
| S-EPMC108317 | biostudies-literature
Unknown Helicobacter pylori γ-glutamyl transpeptidase and vacuolating cytotoxin promote gastric persistence and immune tolerance.
| S-EPMC3581963 | biostudies-literature
Unknown Outer membrane targeting of passenger proteins by the vacuolating cytotoxin autotransporter of Helicobacter pylori.
| S-EPMC100054 | biostudies-literature
Unknown Amino-terminal hydrophobic region of Helicobacter pylori vacuolating cytotoxin (VacA) mediates transmembrane protein dimerization.
| S-EPMC98002 | biostudies-literature
Unknown The m2 form of the Helicobacter pylori cytotoxin has cell type-specific vacuolating activity.
| S-EPMC21487 | biostudies-literature