Catehol-o-methyltransferase gene Val158met polymorphism as a potential predictor of response to computer-assisted delivery of cognitive-behavioral therapy among cocaine-dependent individuals: Preliminary findings from a randomized controlled trial.

ABSTRACT:

Background

Findings from uncontrolled studies suggest that the COMT Val108/158Met polymorphism may affect response to cognitive behavioral therapy (CBT) in some populations. Using data from a randomized controlled trial evaluating computerized CBT (CBT4CBT), we evaluated treatment response by COMT genotype, with the a priori hypothesis that Val carriers would have improved response to computerized delivery of CBT.

Methods

101 cocaine-dependent individuals, of whom 81 contributed analyzable genetic samples, were randomized to standard methadone maintenance treatment plus CBT4CBT or standard treatment alone in an 8 week trial.

Results

There was a significant genotype by time effect on frequency of cocaine use from baseline to the end of the 6 month follow-up, suggesting

SUBMITTER: Carroll KM 

PROVIDER: S-EPMC4516567 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature