Therapeutic strategies for anchored kinases and phosphatases: exploiting short linear motifs and intrinsic disorder.

ABSTRACT: Phosphorylation events that occur in response to the second messenger cAMP are controlled spatially and temporally by protein kinase A (PKA) interacting with A-kinase anchoring proteins (AKAPs). Recent advances in understanding the structural basis for this interaction have reinforced the hypothesis that AKAPs create spatially constrained signaling microdomains. This has led to the realization that the PKA/AKAP interface is a potential drug target for modulating a plethora of cell-signaling events. Pharmacological disruption of kinase-AKAP interactions has previously been explored for disease treatment and remains an interesting area of research. However, disrupting or enhancing the association of phosphatases with AKAPs is a therapeutic concept of equal promise, particularly since they op

SUBMITTER: Nygren PJ 

PROVIDER: S-EPMC4516873 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature