Ontology highlight
ABSTRACT:
SUBMITTER: Wijnands KA
PROVIDER: S-EPMC4516994 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Wijnands Karolina A P KA Meesters Dennis M DM van Barneveld Kevin W Y KW Visschers Ruben G J RG Briedé Jacob J JJ Vandendriessche Benjamin B van Eijk Hans M H HM Bessems Babs A F M BA van den Hoven Nadine N von Wintersdorff Christian J H CJ Brouckaert Peter P Bouvy Nicole D ND Lamers Wouter H WH Cauwels Anje A Poeze Martijn M
Nutrients 20150629 7
Enhanced arginase-induced arginine consumption is believed to play a key role in the pathogenesis of sickle cell disease-induced end organ failure. Enhancement of arginine availability with L-arginine supplementation exhibited less consistent results; however, L-citrulline, the precursor of L-arginine, may be a promising alternative. In this study, we determined the effects of L-citrulline compared to L-arginine supplementation on arginine-nitric oxide (NO) metabolism, arginine availability and ...[more]