Resistance against Integrase Strand Transfer Inhibitors and Relevance to HIV Persistence.

ABSTRACT: Drug resistance prevents the successful treatment of HIV-positive individuals by decreasing viral sensitivity to a drug or a class of drugs. In addition to transmitted resistant viruses, treatment-naïve individuals can be confronted with the problem of drug resistance through de novo emergence of such variants. Resistant viruses have been reported for every antiretroviral drug tested so far, including the integrase strand transfer inhibitors raltegravir, elvitegravir and dolutegravir. However, de novo resistant variants against dolutegravir have been found in treatment-experienced but not in treatment-naïve individuals, a characteristic that is unique amongst antiretroviral drugs. We review here the issue of drug resistance against integrase strand transfer inhibitors as well as both pre-c

SUBMITTER: Mesplede T 

PROVIDER: S-EPMC4517119 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature