Ontology highlight
ABSTRACT:
SUBMITTER: Luongo TS
PROVIDER: S-EPMC4517182 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Cell reports 20150625 1
Cardiac contractility is mediated by a variable flux in intracellular calcium (Ca(2+)), thought to be integrated into mitochondria via the mitochondrial calcium uniporter (MCU) channel to match energetic demand. Here, we examine a conditional, cardiomyocyte-specific, mutant mouse lacking Mcu, the pore-forming subunit of the MCU channel, in adulthood. Mcu(-/-) mice display no overt baseline phenotype and are protected against mCa(2+) overload in an in vivo myocardial ischemia-reperfusion injury m ...[more]